PubAg

Main content area

Enantioselective Synthesis of gem-Diaryl Benzofuran-3(2H)-ones via One-Pot Asymmetric Rhodium/Palladium Relay Catalysis

Author:
Zhang, Zong-Feng, Zhu, Dong-Xing, Chen, Wen-Wen, Xu, Bin, Xu, Ming-Hua
Source:
Organic letters 2017 v.19 no.10 pp. 2726-2729
ISSN:
1523-7052
Subject:
catalytic activity, chemical reactions, chemical structure, enantioselective synthesis, enantioselectivity, organic compounds, palladium, rhodium
Abstract:
An asymmetric dual-metal relay catalysis strategy that combines Rh/chiral sulfur-olefin-catalyzed enantioselective 1,2-addition with a Pd-catalyzed intramolecular C–O coupling has been developed. The method allows rapid and efficient synthesis of quaternary carbon-containing gem-diaryl benzofuran-3(2H)-ones in good yields in a highly enantioselective manner (up to 99% ee) through a simple one-pot cascade reaction.
Agid:
5792894