PubAg

Main content area

Rh/DuanPhos-Catalyzed Asymmetric Hydrogenation of β-Acetylamino Vinylsulfides: An Approach to Chiral β-Acetylamino Sulfides

Author:
Gao, Wenchao, Lv, Hui, Zhang, Xumu
Source:
Organic letters 2017 v.19 no.11 pp. 2877-2880
ISSN:
1523-7052
Subject:
chemical structure, hydrogenation, organic compounds, sulfides
Abstract:
Rh/DuanPhos-catalyzed asymmetric hydrogenation of challenging β-acetylamino vinylsulfides has been developed, affording chiral β-acetylamino sulfides with high yields and excellent ee’s (up to 99% ee). This novel methodology provides an efficient and concise synthetic route to chiral β-acetylamino sulfides. The potential utility of this protocol in the synthesis of Apremilast has also been disclosed.
Agid:
5792934