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Ruthenium(0)-Catalyzed C–C Coupling of Alkynes and 3-Hydroxy-2-oxindoles: Direct C–H Vinylation of Alcohols

Author:
Luong, Tom, Chen, Shujie, Qu, Ke, McInturff, Emma L., Krische, Michael J.
Source:
Organic letters 2017 v.19 no.4 pp. 966-968
ISSN:
1523-7052
Subject:
alcohols, alkynes, catalysts, chemical reactions, chemical structure, geometry, olefin, regioselectivity, ruthenium
Abstract:
Upon exposure to a ruthenium(0) catalyst, N-benzyl-3-hydroxy-2-oxindoles react with diverse alkynes to form products of C–H vinylation with complete control of regioselectivity and olefin geometry. This method contributes to a growing body of catalytic processes that enable direct conversion of lower alcohols to higher alcohols in the absence of stoichiometric organometallic reagents.
Agid:
5793417