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Beyond a Carrier: Graphene Quantum Dots as a Probe for Programmatically Monitoring Anti-Cancer Drug Delivery, Release, and Response

Author:
Ding, Hui, Zhang, Fan, Zhao, Chaochao, Lv, Yanlin, Ma, Guanghui, Wei, Wei, Tian, Zhiyuan
Source:
ACS applied materials & interfaces 2017 v.9 no.33 pp. 27396-27401
ISSN:
1944-8252
Subject:
apoptosis, doxorubicin, fluorescence, graphene, monitoring, neoplasms, physicochemical properties, quantum dots
Abstract:
On the basis of the unique physicochemical properties of graphene quantum dots (GQDs), we developed a novel type of theranostic agent by loading anticancer drug doxorubicin (DOX) to GQD’s surface and conjugating Cy5.5 (Cy) dye to GQD though a cathepsin D-responsive (P) peptide. Such type of agents demonstrated superior therapeutic performance both in vitro and in vivo because of the improved tissue penetration and cellular uptake. More importantly, they are capable of functioning as probes for programmed tracking the delivery and release of anticancer drug as well as drug-induced cancer cell apoptosis through GQD’s, DOX’s, and Cy’s charateristic fluorescence, respectively.
Agid:
5795681