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Chemical Constituents with Proprotein Convertase Subtilisin/Kexin Type 9 mRNA Expression Inhibitory Activity from Dried Immature Morus alba Fruits
- Pel, Pisey, Chae, Hee-Sung, Nhoek, Piseth, Kim, Young-Mi, Chin, Young-Won
- Journal of agricultural and food chemistry 2017 v.65 no.26 pp. 5316-5321
- Morus alba, chemical composition, fruits, gene expression, human cell lines, inhibitory concentration 50, messenger RNA, monitoring, nuclear magnetic resonance spectroscopy, spectral analysis, subtilisin
- Phytochemical investigation for a chloroform-soluble extract of dried Morus alba fruits, selected by proprotein convertase subtilisin-kexin type 9 (PCSK9) mRNA expression monitoring assay in HepG2 cells, led to the isolation of a new benzofuran, isomoracin D (1), and a naturally occurring compound, N-(N-benzoyl-l-phenylalanyl)-l-phenylalanol (2), along with 13 known compounds (3–15). All of the structures were established by NMR spectroscopic data as well as MS analysis. Of the isolates, moracin C (7) was found to inhibit PCSK9 mRNA expression with an IC50 value of 16.8 μM in the HepG2 cells.