PubAg

Main content area

Palladium-Catalyzed Incorporation of Two C1 Building Blocks: The Reaction of Atmospheric CO2 and Isocyanides with 2-Iodoanilines Leading to the Synthesis of Quinazoline-2,4(1H,3H)-diones

Author:
Xu, Pei, Wang, Fei, Wei, Tian-Qi, Yin, Ling, Wang, Shun-Yi, Ji, Shun-Jun
Source:
Organic letters 2017 v.19 no.17 pp. 4484-4487
ISSN:
1523-7052
Subject:
atmospheric pressure, carbon dioxide, catalytic activity, chemical bonding, chemical structure, cycloaddition reactions, organic compounds, palladium
Abstract:
A Pd-catalyzed insertion and cycloaddition of CO₂ and isocyanide into 2-iodoanilines under atmospheric pressure has been developed and affords quinazoline-2,4(1H,3H)-diones through the formation of new C–C, C–O, and C–N bonds under mild conditions. This reaction provides a new and practical method not only for the construction of quinazoline-2,4(1H,3H)-diones but also for the efficient utilization of carbon dioxide.
Agid:
5798121