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Absorption, Distribution, Metabolism, and in Vitro Digestion of Beta-Cypermethrin in Laying Hens
- Liu, Xueke, Wang, Peng, Liu, Chang, Liang, Yiran, Zhou, Zhiqiang, Liu, Donghui
- Journal of agricultural and food chemistry 2017 v.65 no.35 pp. 7647-7652
- absorption, blood, digestion, eggs, human health, humans, in vitro digestion, laying hens, metabolism, metabolites, models, risk, tissues
- Beta-cypermethrin (beta-CP), an important pyrethroid insecticide, and its main acid metabolites are frequently detected in human samples. Because beta-CP may pose some risk to human health, we studied dynamics and residues of beta-CP and its metabolites in hen egg, droppings, blood, and 15 other tissues after continuous exposure. A digestive model was then used to study beta-CP’s digestive fate. Beta-CP and its metabolites significantly accumulated in tissues with high lipid contents and were readily transferred to eggs. Beta-CP was mainly metabolized into acid metabolites that accumulated in egg and edible tissues of laying hens, suggesting that humans may be exposed to beta-CP acid metabolites through food.