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Pharmacokinetics of Rhodamine 110 and Its Organ Distribution in Rats

Author:
Jiang, Shiau-Han, Cheng, Yung-Yi, Huo, Teh-Ia, Tsai, Tung-Hu
Source:
Journal of agricultural and food chemistry 2017 v.65 no.35 pp. 7797-7804
ISSN:
1520-5118
Subject:
bioavailability, dyes, food additives, high performance liquid chromatography, kidneys, liver, oral administration, pharmacokinetics, rats, tandem mass spectrometry
Abstract:
Rhodamine dyes have been banned as food additives due to their potential tumorigenicity. Rhodamine 110 is illegal as a food additive, although its pharmacokinetics have not been characterized, and no accurate bioanalytical methods are available to quantify rhodamine 110. The aim of this study was to develop and validate a fast, stable, and sensitive method to quantify rhodamine 110 using high-performance liquid chromatography coupled to tandem mass spectrometry (HPLC-MS/MS) to assess its pharmacokinetics and organ distribution in awake rats. Rhodamine 110 exhibited linear pharmacokinetics and slow elimination after oral administration. Furthermore, its oral bioavailability was approximately 34–35%. The distribution in the liver and kidney suggests that these organs are primarily responsible for rhodamine 110 metabolism and elimination. Our investigation describes the pharmacokinetics and a quantification method for rhodamine 110, improving our understanding of the food safety of rhodamine dyes.
Agid:
5799834