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Surfactant effects on the particle size, zeta potential, and stability of starch nanoparticles and their use in a pH-responsive manner

Masoudipour, Elham, Kashanian, Soheila, Azandaryani, Abbas Hemati, Omidfar, Kobra, Bazyar, Elham
Cellulose 2017 v.24 no.10 pp. 4217-4234
acid hydrolysis, antineoplastic agents, carbon dioxide, cellulose, corn starch, nanocarriers, nanoparticles, pH, particle size, particle size distribution, potato starch, scanning electron microscopy, sodium bicarbonate, starch, storage, storage conditions, surfactants, ultrasonic treatment, zeta potential
Storage conditions seem to be important in the long-term stability of nanoparticles (NPs). This work studies the effects of surfactants and storage container on particle size distribution and zeta potential during long-term storage of acid hydrolyzed potato starch NPs. The NPs were prepared from potato starch using acid hydrolysis and high-intensity ultrasonication. During the ultrasonic treatment, the surfactants were added dropwise to the solutions to reduce the size and stabilize the formed NPs. Particle size distribution, zeta potential, and FE-SEM were used to characterize the ensuing NPs. Additionally, a 5-month stability study was performed to evaluate the maintenance of potato starch NPs over time at different storage conditions. Then, NPs from corn starch were produced by the same procedure and were used for preparing pH-responsive nanocarriers containing NaHCO₃ for delivery of an anti-cancer drug, FTY720. These NPs were able to release the drug at pH 5.0 because of CO₂ generated from NaHCO₃ in acidic pH and released from the NPs by the production of pores, which accelerate drug release.