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Breed characteristics associated with LEP gene polymorphisms in Holstein cattle

Machulskaya, E. V., Kovalyuk, N. V., Gorkovenko, L. G., Shakhnazarova, Yu. Yu., Morkovkina, N. A.
Russian agricultural sciences 2017 v.43 no.4 pp. 314-316
Holstein, agricultural sciences, alleles, cows, genotyping, heifers, herds, heterozygosity, homozygosity, lactation, leptin, loci, longevity, marker-assisted selection, single nucleotide polymorphism, surveys
Genotyping of the leptin gene locus (LEP) (SNP: R25C, Y7F, and A80V) has been performed in the animals from two groups in the Holstein cattle herd. Groups 1 and 2 included the fourth to seventh lactation cows and the heifers, respectively. The objective of the surveys was to study the Holstein cattle polymorphisms of the leptin gene associated with the productive longevity according to the related literature data. It has been ascertained that the LEP gene (SNP: R25C, Y7F, and A80V) polymorphism in the Holstein animals determines the certain breed characteristics that can be used for introduction to marker assisted selection. (Particularly, a low (0.04–0.15) frequency of occurrence of the F allele is typical for the LEP-Y7F SNP; as for SNP LEP-A80V, a low frequency of occurrence (0–0.14) is typical for the homozygous animals with the VV genotype when compared to a rather high frequency of occurrence (0.36–0.45) in the heterozygous animals).