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Magnesium supplementation improves indicators of low magnesium status and inflammatory stress in adults older than 51 years with poor quality sleep

Forrest H. Nielsen, Luann K. Johnson, Huawei Zeng
Magnesium Research 2010 v.23 no.4 pp. 158-168
C-reactive protein, Estimated Average Requirement, blood, body mass index, dietary mineral supplements, females, food records, humans, inflammation, magnesium, males, middle-aged adults, nutrient deficiencies, nutritional status, oxidative stress, sleep, statistical analysis, urine
Low magnesium status has been associated with numerous conditions characterized as having a chronic inflammatory stress component. Some animal findings indicate that a moderate magnesium deficiency, similar to which apparently commonly occurs in humans, may enhance inflammatory or oxidative stress induced by other factors, including disrupted sleep/sleep deprivation. Thus, an experiment was performed with 100 adults (22 males and 78 females) older than 51 years with poor sleep quality revealed by a Pittsburg Sleep Quality Index (PSQI) score higher than five. The participants were randomly assigned to two groups matched by gender, age, and overall PSQI score. After baseline assessment (week one) of body mass index (BMI), diet, blood and urine biochemical variables, and sleep quality, one group was given a 320 mg magnesium/day supplement as magnesium citrate and the other group a sodium citrate placebo for seven weeks. Final assessments were made five and seven weeks (which were combined for statistical analysis to reduce intra-individual variation) after supplement initiation for the 96 participants that completed the study as designed. Based on food diaries, 58% of the participants were consuming less than the U.S. Estimated Average Requirement (EAR) for magnesium. Consuming less than the EAR was associated with significantly higher BMI and plasma C-reactive protein (CRP) concentration. Only 40 participants had plasma CRP concentrations higher than 3.0 mg/L (an indication of chronic inflammatory stress). Overall PSQI scores improved (10.4 to 6.6, p