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An efficient metal-free cascade process for the synthesis of 4-arylpyrimido[1,2-b]indazole-3-carbonitrile derivatives

Author:
Li, Lei, Xu, Hui, Dai, Lei, Xi, Junhua, Gao, Lingli, Rong, Liangce
Source:
Tetrahedron 2017 v.73 pp. 5358-5365
ISSN:
0040-4020
Subject:
aldehydes, chemical reactions, chemical structure, ethanol, triethylamine
Abstract:
An efficient metal-free cascade reaction to synthesize novel pyrimido[1,2-b]indazole-3-carbonitrile derivatives was reported. The reaction starts from aromatic aldehydes, 1H-indazol-3-amine (4-chloro-1H-indazol-3-amine), and 3-(1H-indol-3-yl)-3-oxopropanenitrile or 3-oxo-3-arylpro-panenitrile in the presence of ethanol and triethylamine under plain laboratory conditions. The reaction was easy to operate with good tolerance to substrates in high yield.
Agid:
5809623