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A benzothizole-based fluorescent probe for Hg2+ recognition utilizing ESIPT coupled AIE characteristics

Author:
Xu, Dong, Tang, Lijun, Tian, Mingyu, He, Ping, Yan, Xiaomei
Source:
Tetrahedron letters 2017
ISSN:
0040-4039
Subject:
chemical reactions, chemical structure, fluorescence, fluorescent dyes, image analysis, ions, mercury, organic compounds, pH, toxicity
Abstract:
A new benzothizole-based fluorescent probe 1 for Hg2+ recognition utilizing “ESIPT+AIE” strategy has been developed. In THF/H2O (1:1, v/v, PBS 20 mM, pH = 8.5) mixed solution, probe 1 displays rapid fluorescence responses to Hg2+ ions with high selectivity and sensitivity through Hg2+-triggered releasing of a compound possessing “ESIPT+AIE” characteristics. Cell imaging investigations indicate that probe 1 is cell permeable with low toxicity to MCF-7 cells, and applicable to detect Hg2+ ions in living MCF-7 cells.
Agid:
5809706