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The Ribosome Holds the RNA Polymerase on Track in Bacteria
- Klaholz, Bruno P.
- Trends in biochemical sciences 2017 v.42 no.9 pp. 686-689
- DNA-directed RNA polymerase, bacteria, molecular biology, ribosomes, transcription (genetics), translation (genetics)
- The central dogma of molecular biology comprises two fundamental mechanistic steps of gene expression (transcription and translation), which, in bacteria, are coupled. A recent study provides structural insights into a supercomplex between the RNA polymerase and the ribosome, thus highlighting the synergy between two key macromolecular machineries in the cell.