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Alginate modified with maleimide-terminated PEG as drug carriers with enhanced mucoadhesion

Author:
Shtenberg, Yarden, Goldfeder, Mor, Schroeder, Avi, Bianco-Peled, Havazelet
Source:
Carbohydrate polymers 2017 v.175 pp. 337-346
ISSN:
0144-8617
Subject:
alginates, biocompatible materials, cylinders, drug carriers, fibroblasts, glycoproteins, humans, hydrogen bonding, mucus, polyethylene glycol, viability
Abstract:
The goal of this study was to generate a new mucoadhesive carbohydrate-based delivery system composed of alginate (Alg) backbone covalently attached to polyethylene glycol (PEG) modified with a unique functional end-group (maleimide). The immobilization of PEG-maleimide chains significantly improved the mucoadhesion properties attributed to thioether bonds creation via Michael-type addition and hydrogen bonding with the mucus glycoproteins. Mucoadhesion studies using tensile and rotating cylinder assays revealed a 3.6-fold enhanced detachment force and a 2.8-fold enhanced retention time compared to the unmodified polymer, respectively. Additional indirect studies confirmed the presence of polymer-mucus glycoproteins interactions.Drug release experiments were used to evaluate the release profiles from Alg-PEG-maleimide tablets in comparison to Alg and Alg-SH tablets. Viability studies of normal human dermal fibroblasts cells depicted the non-toxic nature of Alg-PEG-maleimide. Overall, our studies disclose that PEG-maleimide substitutions on other biocompatible polymers can lead to the development of useful biomaterials for diverse biomedical applications.
Agid:
5814892