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p-TSA-catalyzed facile and efficient one-pot eco-friendly synthesis of novel isoxazolyl amino furo[3,2-c]quinolinone derivatives in aqueous medium

Author:
Modugu, Nagi Reddy, Pittala, Praveen Kumar
Source:
Tetrahedron letters 2017 v.58 pp. 3859-3863
ISSN:
0040-4039
Subject:
catalysts, chemical reactions, chemical structure, quinolones, solvents
Abstract:
A green and operationally simple approach for the synthesis of novel isoxazolyl amino furo[3,2-c]quinolinone derivatives by a one-pot three-component reaction of 4-amino-3-methyl-5 styrylisoxazoles, aryl glyoxal monohydrates and 4-hydroxy-1-methyl-2-quinolinone using p-TSA as the catalyst in aqueous medium was developed. The protocol proves to be an efficient and an environmentally benign in terms of high yields, operational simplicity, clean reaction profile, compatibility with wide range of substrates, water as a solvent and easy purification.
Agid:
5815200