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Characterization and antifungal activity against Pestalotiopsis of a fusaricidin-type compound produced by Paenibacillus polymyxa Y-1

Yang, Anming, Zeng, Song, Yu, Lu, He, Ming, Yang, Yuanyou, Zhao, Xiaozhen, Jiang, Chaolin, Hu, Deyu, Song, Baoan
Pesticide biochemistry and physiology 2018 v.147 pp. 67-74
Dendrobium nobile, Paenibacillus polymyxa, Pestalotiopsis, amino acids, antifungal properties, bacteria, biological control, biosynthesis, electron transport chain, endophytes, energy, herbal medicines, metabolites, proteomics, raw materials
Dendrobium nobile (D. nobile) is a valuable Chinese herbal medicine. The discovery of microbial resources from has provided a wealth of raw materials. Stalk rot, which is caused by Pestalotiopsis, is one of the most serious diseases of D nobile and has resulted in serious losses in production. However, an effective method for the prevention and control of stalk rot remains lacking. In this study, we aimed to identify a biocontrol strain against Pestalotiopsis. We isolated Paenibacillus polymyxa Y-1, an endophytic bacterium, from the stem of D. nobile. Three pairs of active metabolites isolated from this bacterium were identified as fusaricidin compounds. We then investigated the mechanism of fusaricidin compounds on Pestalotiopsis via proteomics. Proteomics data showed that the compounds mainly inhibit energy generation in the respiratory chain and amino acid biosynthesis of Pestalotiopsis.