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A high-fat diet and the threonine-encoding allele (Thr54) polymorphism of fatty acid–binding protein 2 reduce plasma triglyceride–rich lipoproteins

McColley, Steven P, Georgeopoulos, Angeliki, Young, Lindsay R, Kurzer, Mindy A, Redmon, J. Bruce, Raatz, Susan K
Nutrition research 2011 v.31 pp. 503
DNA, alleles, blood lipids, energy, fatty acid-binding proteins, high fat diet, lipid content, low density lipoprotein, omega-3 fatty acids, triacylglycerols, women
The Thr54 allele of the fatty acid binding protein 2 (FABP2) DNA polymorphism is associated with increased triglyceride-rich lipoproteins and insulin resistance. We investigated whether the triglyceride-rich lipoprotein response to diets of varied fat content is affected by the fatty acid binding protein-2 A54T polymorphism. Sixteen healthy, post-menopausal women completed a cross-over dietary intervention that included three 8-week, isocaloric diet treatments. The treatments consisted of high fat (HF, 40% of energy as fat), low fat (LF, 20% of energy), and low fat + omega-3 fatty acids (LF+n3, 20% of energy plus 3% as omega-3 fatty acids). Eight subjects were homozygous for the wild-type (A/A) of the FABP2 polymorphism while eight subjects had at least one Thr54 allele (7 = A/T, 1 = T/T). Carriers of the Thr54 allele of the FABP2 polymorphism who consumed the HF diet showed significantly reduced plasma triglycerides (TG), chylomicron TG, and very-low density lipoprotein (VLDL) and chylomicron remnant (CR) TG from baseline, but as this is contrary to previous literature, the change is likely due to the effect of the diet rather than genotype. The Ala54 allele did not influence the dietary effects on the plasma lipids. Apolipoprotein E polymorphism (ApoE) and HOMA-IR score did not significantly change plasma TG, chylomicron TG, or VLDL and CR TG from baseline.