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Cytotoxic and antibacterial activities of iridoids and sesquiterpenoids from Valeriana jatamansi
- Liu, Ying-Hong, Wu, Pei-Qian, Hu, Qiao-Ling, Pei, Yue-Juan, Qi, Feng-Ming, Zhang, Zhan-Xin, Fei, Dong-Qing
- Fitoterapia 2017
- Pseudomonas aeruginosa, Staphylococcus aureus, Valeriana jatamansi, X-ray diffraction, antibacterial properties, bacteria, cytotoxicity, inhibitory concentration 50, iridoids, irradiation, medicinal plants, neoplasms, nuclear magnetic resonance spectroscopy, roots, sesquiterpenoids, spectral analysis
- Three new iridoids, valejatanins A–C (1–3), and one new natrual iridoid (4), together with four known sesquiterpenoids (5–8), were isolated from the roots of Valeriana jatamansi Jones. Compounds 3 and 4 are C(4)-epimers. Their structures were elucidated by extensive spectroscopic analysis (IR, HRESIMS, 1D and 2D NMR) and by comparison of their NMR data with those of related compounds. The absolute configuration of 5 was determined for the first time by single-crystal X-ray diffraction analysis with Cu-Kα irradiation. The cytotoxic activities of all compounds were evaluated against HT29, K562 and B16 cancer cell lines in vitro by MTT assay. Valejatanin A (1) showed noteworthy cytotoxic activities with IC50 values of 22.17, 15.26, 3.53μg/mL against three cancer cell lines. The antibacterial activities of all compounds against bacteria were tested in vitro. Valejatanin A (1) exhibited antibacterial activities against Staphylococcus aureus and Pseudomonas aeruginosa.