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Cytotoxic and antibacterial activities of iridoids and sesquiterpenoids from Valeriana jatamansi

Liu, Ying-Hong, Wu, Pei-Qian, Hu, Qiao-Ling, Pei, Yue-Juan, Qi, Feng-Ming, Zhang, Zhan-Xin, Fei, Dong-Qing
Fitoterapia 2017
Pseudomonas aeruginosa, Staphylococcus aureus, Valeriana jatamansi, X-ray diffraction, antibacterial properties, bacteria, cytotoxicity, inhibitory concentration 50, iridoids, irradiation, medicinal plants, neoplasms, nuclear magnetic resonance spectroscopy, roots, sesquiterpenoids, spectral analysis
Three new iridoids, valejatanins A–C (1–3), and one new natrual iridoid (4), together with four known sesquiterpenoids (5–8), were isolated from the roots of Valeriana jatamansi Jones. Compounds 3 and 4 are C(4)-epimers. Their structures were elucidated by extensive spectroscopic analysis (IR, HRESIMS, 1D and 2D NMR) and by comparison of their NMR data with those of related compounds. The absolute configuration of 5 was determined for the first time by single-crystal X-ray diffraction analysis with Cu-Kα irradiation. The cytotoxic activities of all compounds were evaluated against HT29, K562 and B16 cancer cell lines in vitro by MTT assay. Valejatanin A (1) showed noteworthy cytotoxic activities with IC50 values of 22.17, 15.26, 3.53μg/mL against three cancer cell lines. The antibacterial activities of all compounds against bacteria were tested in vitro. Valejatanin A (1) exhibited antibacterial activities against Staphylococcus aureus and Pseudomonas aeruginosa.