PubAg

Main content area

Isoprenylated phenolic compounds with PTP1B inhibition from Morus alba

Author:
Huang, Qing-Hua, Lei, Chun, Wang, Pei-Pei, Li, Jing-Ya, Li, Jia, Hou, Ai-Jun
Source:
Fitoterapia 2017 v.122 pp. 138-143
ISSN:
0367-326X
Subject:
Morus alba, bark, cycloaddition reactions, inhibitory concentration 50, medicinal plants, nuclear magnetic resonance spectroscopy, phenolic compounds, spectral analysis
Abstract:
Two new Diels-Alder adducts, albasins A and B (1 and 2), one new isoprenylated 2-arylbenzofuran, albasin C (3), one new isoprenylated flavone, albasin D (4), together with sixteen known phenolic compounds, were isolated from the root bark of Morus alba. Their structures were elucidated by extensive spectroscopic analysis, including NMR, MS, and ECD data. All the new compounds and most of the known ones showed significant inhibitory effects on PTP1B in vitro with IC50 values ranging from 0.57 to 7.49μM.
Agid:
5824622