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Base-Mediated Synthesis of Unsymmetrical 1,3,5-Triazin-2-amines via Three-Component Reaction of Imidates, Guanidines, and Amides or Aldehydes

Author:
Pan, Liyang, Li, Zhenxing, Ding, Tao, Fang, Xiaomin, Zhang, Wenkai, Xu, Hao, Xu, Yuanqing
Source:
Journal of organic chemistry 2017 v.82 no.19 pp. 10043-10050
ISSN:
1520-6904
Subject:
aldehydes, amides, catalysts, cesium, chemical reactions, guanidines, imidoesters, moieties, organic chemistry
Abstract:
A simple and efficient method for the base-mediated synthesis of unsymmetrical 1,3,5-triazin-2-amines has been developed. The protocol uses readily available imidates, guanidines, and amides or aldehydes as the starting materials, cesium carbonate as the base, no catalyst or additive is required, and the three-component reaction provides diverse 1,3,5-triazin-2-amines in moderate to good yields with tolerance of wide functional groups.
Agid:
5826803