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Catalytic One-Pot Synthesis of Trisubstituted Allenes from Terminal Alkynes and Ketones

Author:
Liu, Qi, Tang, Xinjun, Cai, Yujuan, Ma, Shengming
Source:
Organic letters 2017 v.19 no.19 pp. 5174-5177
ISSN:
1523-7052
Subject:
alkynes, allene, chemical reactions, chemical structure, ketones, synthesis
Abstract:
An efficient one-pot synthesis of trisubstituted allenes from readily available terminal alkynes and ketones is realized. A wide range of trisubstituted allenes may be synthesized efficiently via this method. Preliminary mechanistic studies revealed that CuI and Ti(OEt)₄ are in charge of the formation of propargylic amine, while ZnBr₂ is responsible for the transformation from propargylic amine to allene.
Agid:
5826957