PubAg

Main content area

Artemisians A–D, Diseco-guaianolide Involved Heterodimeric [4 + 2] Adducts from Artemisia argyi

Author:
Xue, Gui-Min, Han, Chao, Chen, Chen, Li, Ling-Nan, Wang, Xiao-Bing, Yang, Ming-Hua, Gu, Yu-Cheng, Luo, Jian-Guang, Kong, Ling-Yi
Source:
Organic letters 2017 v.19 no.19 pp. 5410-5413
ISSN:
1523-7052
Subject:
Artemisia argyi, Oriental traditional medicine, apoptosis, chemical structure, circular dichroism spectroscopy, cycloaddition reactions, inhibitory concentration 50, organic compounds, spectral analysis
Abstract:
Artemisians A–D (1–4), the first examples of [4 + 2] Diels–Alder type adducts presumably biosynthesized from a rare 1, 10-4, 5-diseco-guaianolide and a guaianolide diene, along with their possible precursor 5, were isolated from the traditional Chinese medicine Artemisia argyi. The structures of 1–4 were elucidated by extensive spectroscopic analyses and calculated electronic circular dichroism. Compound 2, with an IC₅₀ value of 3.21 μM, exhibited significant antiproliferative activity via apoptosis induction and G2/M arrest in MDA-MB-468 cells.
Agid:
5827015