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Triterpenoids from the bark of Dysoxylum hainanense and their anti-inflammatory and radical scavenging activity

Author:
Zou, Yu-Hai, Liu, Wen-Ting, Zhang, Jin-Xia, Xiang, Ding-Cheng
Source:
Fitoterapia 2017 v.121 pp. 159-163
ISSN:
0367-326X
Subject:
2,2-diphenyl-1-picrylhydrazyl, Dysoxylum, anti-inflammatory activity, antioxidant activity, bark, ethanol, hydroxyl radicals, mass spectrometry, medicinal plants, nuclear magnetic resonance spectroscopy, triterpenoids
Abstract:
A phytochemical investigation on the 70% EtOH extract of the bark of Dysoxylum hainanense resulted in the isolation of four new triterpenoids, dysoxyhaines A–D (1–4). Structural elucidation of all the compounds were performed by spectral methods such as 1D and 2D (1H1H COSY, HMQC, and HMBC) NMR spectroscopy, in addition to high resolution mass spectrometry. The isolated components were evaluated in vitro for anti-inflammatory activities for Cox-1 and Cox-2, and radical scavenging potential using ABTS·+ and DPPH test. As a result, nor seco-olean type triterpenoid 1 exhibited significant anti-inflammatory potential, while tirucallane triterpenoids 3 and 4 showed radical scavenging activities.
Agid:
5828597