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Benzophenone glycosides from the flower buds of Aquilaria sinensis

Author:
Yuan, Hanwen, Zhao, Jianping, Wang, Mei, Khan, Shabana I., Zhai, Chunmei, Xu, Qiongming, Huang, Jianhua, Peng, Caiyun, Xiong, Guanghua, Wang, Wei, Khan, Ikhlas A.
Source:
Fitoterapia 2017 v.121 pp. 170-174
ISSN:
0367-326X
Subject:
benzophenones, inhibitory concentration 50, transcription factor NF-kappa B, buds, nuclear magnetic resonance spectroscopy, methanol, cytotoxicity, medicinal plants, spectral analysis, glycosides, chemical structure, Aquilaria sinensis
Abstract:
Four new benzophenone glycosides named as aquilaside A–D (1–4) along with five known compounds (5–9) were isolated from the methanol extract of the flower buds of Aquilaria sinensis. Their structures were elucidated on the basis of 1D and 2D NMR and mass spectroscopic analyses. All purified compounds were evaluated for their anti-inflammatory and cytotoxic activities. Aquilasides B and C displayed moderate cytotoxicity against SK-MEL cells with IC50 of 17.0 and 12.0μM and weak NF-κB inhibitive activity at 100μM with 30% and 60%, respectively.
Agid:
5828600