U.S. flag

An official website of the United States government

Dot gov

Official websites use .gov
A .gov website belongs to an official government organization in the United States.


Secure .gov websites use HTTPS
A lock ( ) or https:// means you’ve safely connected to the .gov website. Share sensitive information only on official, secure websites.


Main content area

Phenolic glycosides and monoterpenoids from the roots of Euphorbia ebracteolata and their bioactivities

An-Hua Wang, Xiao-Kui Huo, Lei Feng, Cheng-Peng Sun, Sa Deng, Hou-Li Zhang, Bao-Jing Zhang, Xiao-Chi Ma, Jing-Ming Jia, Chao Wang
Fitoterapia 2017 v.121 pp. 175-182
2,2-diphenyl-1-picrylhydrazyl, Euphorbia, anticarcinogenic activity, antioxidant activity, ascorbic acid, bioassays, chemical structure, chromatography, cytotoxicity, electrospray ionization mass spectrometry, fluorescence, glucosides, humans, inhibitory concentration 50, medicinal plants, monoterpenoids, neoplasms, nuclear magnetic resonance spectroscopy, phenolic acids, roots, spectral analysis
The bioactive substance investigation of Euphorbia ebracteolata obtained 17 compounds by various chromatographic techniques. Their structures were elucidated using widely spectroscopic data, including ESI-MS, HRESI-MS, CD, 1D- and 2D-NMR, which gave 5 new phenolic glucosides and 4 new monoterpenoids. The phenolic glucosides and monoterpenoids showed the inhibitory effect against the human carboxylesterase-2 (hCE-2) using a fluorescence bioassay in vitro, with the strongest inhibitor compound 4 (IC50 7.17μM). The antioxidant effects of these isolated compounds were evaluated using a DPPH scavenging assay. All of the phenolic acids displayed the DPPH scavenging effect, especially that eight compounds have better effect than vitamin C, with the IC50 values ranging from 4.52 to 7.52μM. Additionally, compounds 1–17 showed no cytotoxic effect against five human cancer cell lines by MTT assay.