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A Guardian Angel Phosphatase for Mainline Carbon Metabolism

Author:
Beaudoin, Guillaume A., Hanson, Andrew D.
Source:
Trends in biochemical sciences 2016 v.41 no.11 pp. 893-894
ISSN:
0968-0004
Subject:
carbon metabolism, enzymes, glycolysis, toxicity
Abstract:
It is increasingly clear that many metabolic enzymes mistakenly form minor but toxic side-products that must be eliminated to maintain normal fluxes. Collard et al. show that this is true of two iconic glycolytic enzymes, and that a hitherto somewhat mysterious phosphatase rescues central carbon metabolism from their mistakes.