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Enhanced antibacterial activity and biocompatibility of zinc-incorporated organic-inorganic nanocomposite coatings via electrophoretic deposition B Biointerfaces
- Huang, Pin, Ma, Kena, Cai, Xinjie, Huang, Dan, Yang, Xu, Ran, Jiabing, Wang, Fushi, Jiang, Tao
- Colloids and surfaces 2017 v.160 pp. 628-638
- Escherichia coli, antibacterial properties, bacteria, biocompatibility, biomedical materials, bone marrow, chitosan, coatings, colloids, electrophoresis, gelatin, in vitro studies, mechanical testing, nanocomposites, orthopedics, patients, rats, stromal cells, surgery, titanium, transmission electron microscopy, zinc, zinc oxide
- Increased use of reconstruction procedures in orthopedics has improved the life of patients undergoing surgery. However, surgical site infection remains a major challenge. Efforts were made to fabricate antibacterial surfaces with good biocompatibility. This present study aimed to fabricate zinc-incorporated chitosan/gelatin (CS/G) nanocomposite coatings on the titanium substrates via electrophoretic deposition (EPD). Physicochemical characterization confirmed that zinc was successfully deposited in a metallic oxide/salt complex status. Transmission electron microscopic (TEM) results observed formation of core-shell nanosized particles released from the coatings. The selected-area electron diffraction (SAED) pattern of the particles presented faces of ZnO with organic background. Mechanical tests showed improved tensile and shear bond strength between substrates and zinc-incorporated coating surfaces. Zinc-incorporated CS/G coatings presented antibacterial abilities against both Gram-negative E. coli and Gram-positive S. aureus in a concentration-dependent manner. The generation of ZnO/Zn²⁺ complex in the coatings may contribute to bacteria inhibition. In vitro study demonstrated that appropriate concentration of zinc could promote proliferative and osteogenic activities of rat bone marrow stromal cells. The present study suggested that zinc-incorporated CS/G coating was a promising candidate for surface modification of biomedical materials.