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Urinary phthalate metabolite concentrations in relation to levels of circulating matrix metalloproteinases in pregnant women

Bedrosian, Leah D., Ferguson, Kelly K., Cantonwine, David E., McElrath, Thomas F., Meeker, John D.
The Science of the total environment 2018 v.613-614 pp. 1349-1352
humans, metabolites, metalloproteinases, phthalates, pregnancy outcome, pregnant women, protein degradation
Phthalate exposure has been shown to be associated with adverse pregnancy outcomes. However, human studies informing relevant mechanistic pathways are lacking. Experimental studies have reported that matrix metalloproteinases (MMPs), which are responsible for extracellular protein degradation, may be upregulated in response to phthalate exposure. In this exploratory study we measured urinary phthalate metabolite concentrations, plasma MMP levels, and relevant covariates among 134 pregnant women. There were statistically significant or suggestive positive relationships between several phthalates, particularly between metabolites of di-(2-ethylhexyl) phthalate, with MMP-1 and MMP-9 levels. Further research is needed to confirm these results and how they may inform the mechanisms involved between phthalate exposure and adverse pregnancy outcomes.