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Guardians of the ERAD Galaxy
- Sun, Zhihao, Brodsky, Jeffrey L.
- Cell 2017 v.171 pp. 267-268
- endoplasmic reticulum, protein degradation, protein folding, proteins
- The endoplasmic reticulum-associated degradation (ERAD) pathway facilitates the disposal of terminally misfolded proteins in the early secretory pathway yet spares folding intermediates from being destroyed. Zhang et al. report on a protein complex that acts as a guardian to protect these folding intermediates from being targeted for ERAD.