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Guardians of the ERAD Galaxy

Author:
Sun, Zhihao, Brodsky, Jeffrey L.
Source:
Cell 2017 v.171 pp. 267-268
ISSN:
0092-8674
Subject:
endoplasmic reticulum, protein degradation, protein folding, proteins
Abstract:
The endoplasmic reticulum-associated degradation (ERAD) pathway facilitates the disposal of terminally misfolded proteins in the early secretory pathway yet spares folding intermediates from being destroyed. Zhang et al. report on a protein complex that acts as a guardian to protect these folding intermediates from being targeted for ERAD.
Agid:
5841380