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New neo-clerodane diterpenoids with neurotrophic activity from the aerial parts of Salvia tiliifolia

Author:
Fan, Min, Bao, Ying, Zhang, Zhi-Jun, Zhang, Hong-Bin, Zhao, Qin-Shi
Source:
Fitoterapia 2017 v.123 pp. 44-50
ISSN:
0367-326X
Subject:
Salvia, aerial parts, cytotoxicity, diterpenoids, humans, in vitro studies, medicinal plants, neoplasms, neuroprotective effect, nuclear magnetic resonance spectroscopy, spectral analysis
Abstract:
Five new neo-clerodane diterpenoids, tiliifolins A–E (1–5), along with ten known ones, were isolated from the aerial part of Salvia tiliifolia. Their structures were proposed based on 1D and 2D NMR spectroscopic data analysis. All new compounds were evaluated for their neurotrophic activity on PC12 cells and cytotoxicity against five human cancer cell lines (HL-60, A-549, SMMC-7721, MCF-7, and SW480), and compound 5 showed statistically significant neuroprotective effect in vitro assay.
Agid:
5841903