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Two new lactones from whole herbs of Patrinia villosa Juss
- Bai, Ming, Liu, Si-Fan, Wang, Wei, Wang, Xiao-Bo, Huang, Xiao-Xiao, Song, Shao-Jiang
- Phytochemistry letters 2017 v.22 pp. 145-148
- Micrococcus luteus, Patrinia villosa, antimicrobial properties, cytotoxicity, ethanol, herbs, lactones, neoplasms, spectral analysis
- Chemical investigation of 70% EtOH exact of Patrinia villosa Juss. led to the isolation, purification and identification of two new lactones (1-2) along with twelve known compounds (3-14). Their structures were established by comprehensive spectroscopic analyses. All compounds were evaluated for their cytotoxic activities against A549, HepG2, Hep3B and MCF-7 cancer cell lines. Compounds 1, 8, 10, 11 and 12 displayed weak cytotoxic activities against MCF-7 cell line. In addition, compounds 1, 2, 8, 10, 11 and 12 were also tested their antimicrobial activities against Micrococcus luteus. Unfortunately, these compounds were found to be inactive.