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Self-assembly of polyelectrolyte complexes microcapsules with natural polysaccharides for sustained drug release
- Wu, Qing-Xi, Wang, Dan-Dan, Su, Ting, Cheng, Xiao-Du, Xu, Xin, Chen, Yan
- Cellulose 2017 v.24 no.11 pp. 4949-4962
- calcium alginate, cellulose, chitosan, drugs, electrolytes, encapsulation, models, sodium, sulfates
- Polyelectrolyte complexes formed with polysaccharides have generated much interest among researchers because of their excellent performances and mild process. In this work, using calcium alginate/sodium cellulose sulfate [CA/NaCS] as template, [CA/NaCS–CHC] ₙ microcapsules with one, two and three outer layers were self-assembled with NaCS and chitosan hydrochloride (CHC). PEC layer assembly on the [CA/NaCS] cores was achieved, which could be observed from the FITC-labeled [CA/NaCS–CHC] ₙ microcapsules. The first and second PEC layer assemblies were available to help slow the drug loss, and the [CA/NaCS–CHC]₂ microcapsules had a maximum drug-loading and encapsulation efficiency of 38.14 ± 4.04 and 64.72 ± 6.86%, respectively. Ritger-Peppas model analysis showed the drug release occurred under the mechanism of Fickian diffusion for the [CA/NaCS] cores, anomalous (non-Fickian) transport for the [CA/NaCS–CHC]₁ and [CA/NaCS–CHC]₂ microcapsules and case-II transport for the [CA/NaCS–CHC]₃ microcapsules. The prepared microcapsules could be used as vehicles for sustained drug release.