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Roselle is cardioprotective in diet-induced obesity rat model with myocardial infarction

Author:
Si, Lislivia Yiang-Nee, Ali, Siti Aishah Mohd, Latip, Jalifah, Fauzi, Norsyahida Mohd, Budin, Siti Balkis, Zainalabidin, Satirah
Source:
Life sciences 2017
ISSN:
0024-3205
Subject:
Hibiscus sabdariffa, animal models, antioxidants, enzymes, fibrosis, functional foods, high fat diet, hypertension, hypertrophy, myocardial infarction, obesity, oxidative stress, patients, protective effect, rats, risk
Abstract:
Obesity increase the risks of hypertension and myocardial infarction (MI) mediated by oxidative stress. This study was undertaken to investigate the actions of roselle aqueous extract (R) on cardiotoxicity in obese (OB) rats and thereon OB rats subjected to MI.Male Sprague-Dawley rats were fed with either normal diet or high-fat diet for 8weeks. Firstly, OB rats were divided into (1) OB and (2) OB+R (100mg/kg, p.o, 28days). Then, OB rats were subjected to MI (ISO, 85mg/kg, s.c, 2days) and divided into three groups: (1) OB+MI, (2) OB+MI+R and (3) OB+MI+enalapril for another 4weeks.Roselle ameliorated OB and OB+MI's cardiac systolic dysfunction and reduced cardiac hypertrophy and fibrosis. The increased oxidative markers and decreased antioxidant enzymes in OB and OB+MI groups were all attenuated by roselle.These observations indicate the protective effect of roselle on cardiac dysfunction in OB and OB+MI rats, which suggest its potential to be developed as a nutraceutical product for obese and obese patients with MI in the future.
Agid:
5846959