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Isobenzofuranones from the aerial parts of Leontopodium leontopodioides (Wild.) Beauv.

Author:
Zhang, Yi, Yang, Yuling, Ruan, Jingya, Chen, Qiu, Li, Jian, Guo, Yuanqiang, Han, Lifeng, Wang, Tao
Source:
Fitoterapia 2017
ISSN:
0367-326X
Subject:
Leontopodium leontopodioides, aerial parts, chemical reactions, circular dichroism spectroscopy, human cell lines, medicinal plants, nuclear magnetic resonance spectroscopy, triacylglycerols
Abstract:
A phytochemical investigation to obtain new triglyceride (TG) accumulation inhibitors resulted in the isolation of six new isobenzofuranones, leontopodiols A (1), B (2), leontopodiosides C (3), D (4), E (5), F (6), together with three known ones (7–9) from the aerial parts of Leontopodium leontopodioides (Willd.) Beauv. The structures of these isolates were identified by routine NMR experiments, optical rotation determination, electronic circular dichroism (ECD) calculation, along with chemical reaction. Moreover, compounds 1, 2, 5, and 7–9 displayed TG accumulation inhibitory effects on HepG2 cells.
Agid:
5848167