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Monoterpenoid indole alkaloids from the leaves of Alstonia scholaris and their NF-κB inhibitory activity

Author:
Yang, Ji, Fu, Jing, Liu, Xin, Jiang, Zhi-Hong, Zhu, Guo-Yuan
Source:
Fitoterapia 2017
ISSN:
0367-326X
Subject:
Alstonia scholaris, indole alkaloids, leaves, medicinal plants, monoterpenoids, nuclear magnetic resonance spectroscopy, spectral analysis, transcription factor NF-kappa B
Abstract:
Four new monoterpenoid indole alkaloids (MIAs), scholarisines P-S (1–4), and 14 known MIAs (5–18) were isolated from the leaves of Alstonia scholaris (L) R. Br. (Apocynaceae). Their structures were elucidated by analyzing their HRESIMS data and NMR spectroscopic data. All of the isolated MIAs were evaluated for their Nuclear Factor-kappa B (NF-κB) inhibitory activity in HepG2-NF-κB-Luc cells. Among them, five compounds (4, 7, 8, 13 and 16) exhibited significant NF-κB inhibitory activity.
Agid:
5848170