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Potential and limitations of Klebsiella pneumoniae as a microbial cell factory utilizing glycerol as the carbon source
- Kumar, Vinod, Park, Sunghoon
- Biotechnology advances 2018 v.36 no.1 pp. 150-167
- Klebsiella pneumoniae, anaerobic conditions, biocatalysts, carbon, ethanol, glycerol, lactic acid, metabolism, succinic acid, value-added products
- Klebsiella pneumoniae is a Gram-negative facultative anaerobe that metabolizes glycerol efficiently under both aerobic and anaerobic conditions. This microbe is considered an outstanding biocatalyst for transforming glycerol into a variety of value-added products. Crude glycerol is a cheap carbon source and can be converted by K. pneumoniae into useful compounds such as lactic acid, 3-hydroxypropionic acid, ethanol, 1,3-propanediol, 2,3-butanediol, and succinic acid. This review summarizes glycerol metabolism in K. pneumoniae and its potential as a microbial cell factory for the production of commercially important acids and alcohols. Although many challenges remain, K. pneumoniae is a promising workhorse when glycerol is used as the carbon source.