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Three new napthalene derivatives from the endophytic fungus Phomopsis fukushii
- Yang, Hai-Ying, Duan, Yan-Qing, Yang, Ye-Kun, Li, Jing, Liu, Xin, Ye, Lin, Mi, Qi-Li, Kong, Wei-Song, Zhou, Min, Yang, Guang-Yu, Li, Xue-Mei, Hu, Qiu-Fen
- Phytochemistry letters 2017 v.22 pp. 266-269
- Diaporthe, Staphylococcus aureus, endophytes, fermented foods, fungi, nuclear magnetic resonance spectroscopy, rhizomes, vancomycin
- An endophytic Phomopsis fukushii was isolated from the rhizome of Paris polyphylla var. yunnanensis, Diaporthaceae family, and three new (1–3) and four known napthalene derivatives (4–7) were isolated from the fermentation products of this fungus. Their structures were elucidated by spectroscopic methods including extensive 1D- and 2D-NMR techniques. Compounds 1–3 were evaluated for their anti-methicillin-resistant Staphylococcus aureus (anti-MRSA) activity with vancomycin as positive control. The results showed that compounds 1–3 showed good inhibitions with MCI valves of 4, 4 and 6 mg/mL, respectively.