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Boronic Acid Accelerated Three-Component Reaction for the Synthesis of α-Sulfanyl-Substituted Indole-3-acetic Acids

Author:
Das, Amrita, Watanabe, Kenji, Morimoto, Hiroyuki, Ohshima, Takashi
Source:
Organic letters 2017 v.19 no.21 pp. 5794-5797
ISSN:
1523-7052
Subject:
catalytic activity, chemical reactions, chemical structure, indole acetic acid, thiols
Abstract:
Boronic acid was used to accelerate a three-component reaction of indoles, thiols, and glyoxylic acids for the synthesis of α-sulfanyl-substituted indole-3-acetic acids. Boronic acid catalysis to activate the α-hydroxy group in α-hydroxycarboxylic acid intermediates and intramolecular assistance by free carboxylic acid were the keys to accelerating the product formation.
Agid:
5851274