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The effect of coffee intake on lysophosphatidylcholines: A targeted metabolomic approach

Miranda, Andreia Machado, Carioca, Antonio Augusto Ferreira, Steluti, Josiane, da Silva, Ismael Dale Cotrim Guerreiro, Fisberg, Regina Mara, Marchioni, Dirce Maria
Clinical nutrition 2017 v.36 no.6 pp. 1635-1641
beverages, bioactive compounds, body mass index, caffeine, drugs, energy intake, fruit consumption, health surveys, humans, low density lipoprotein, lysophosphatidylcholine, mass spectrometry, metabolites, metabolomics, oxidation, per-capita income, phenolic acids, physical activity, regression analysis, vegetables, Brazil
Lysophosphatidylcholines (lysoPC) are known to be a pathological component of oxidized-LDL, and several studies demonstrate its pro-inflammatory properties in vitro. Nevertheless, bioactive compounds found in coffee, such as phenolic acids might inhibit LDL oxidation. The relationship between coffee consumption and lysoPC has not been described previously in humans. The aim of the present study was to assess the association between coffee intake and plasma lysoPC levels in adults.Data was from the “Health Survey of Sao Paulo (ISA-Capital)”, a cross-sectional population-based survey in Sao Paulo, among 169 individuals aged 20 years or older. This population was categorized into three groups: non-coffee consumers (0 mL/day-G1), low coffee consumers (≤100 mL/day-G2), and high coffee consumers (>100 mL/day-G3). Usual coffee intake was estimated by two 24HR and one FFQ, using Multiple Source Method. Quantification of the metabolites was performed by mass spectrometry (FIA-MS/MS and HPLC-MS/MS) and 14 lysoPC species were identified. The association between coffee intake and lysoPC was analyzed by multiple linear regression adjusted for age, sex, household per capita income, smoking, physical activity, body mass index, total energy intake, use of drugs, vegetables and fruit consumption and caffeine intake.LysoPC levels were significantly lower in G3 than in G1, for the lysoPC a C16:1 (β = −0.56; p = 0.014), lysoPC a C18:1 (β = −2.57; p = 0.018), and lysoPC a C20:4 (β = −1.14; p = 0.037). In opposition, the ratios of C16:0/C16:1 and C18:0/18:1 was higher in G3 (β = 5.04; p = 0.025 and β = 0.28; p = 0.003, respectively).LysoPC profile differed according to coffee intake, showing a possible beneficial health effect of this beverage on inflammatory and oxidative processes.