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The Effects of Curcumin and Curcumin–Phospholipid Complex on the Serum Pro‐oxidant–Antioxidant Balance in Subjects with Metabolic Syndrome

Ghazimoradi, Maryam, Saberi‐Karimian, Maryam, Mohammadi, Farzane, Sahebkar, Amirhossein, Tavallaie, Shima, Safarian, Hamideh, Ferns, Gordon A., Ghayour‐Mobarhan, Majid, Moohebati, Mohsen, Esmaeili, Habibollah, Ahmadinejad, Malihe
Phytotherapy research 2017 v.31 no.11 pp. 1715-1721
blood serum, cardiovascular diseases, computer software, curcumin, metabolic syndrome, patients, placebos, risk
Metabolic syndrome (MetS) is defined by a clustering of metabolic and anthropometric abnormalities and is associated by an increased risk of cardiovascular disease. We have investigated the effect of curcumin supplementation on the serum pro‐oxidant–antioxidant balance (PAB) in patients with MetS. This double‐blind, randomized, placebo‐controlled trial was conducted over 6 weeks. Subjects (n = 120) were randomly allocated to one of three groups (curcumin, phospholipidated curcumin, and placebo). The curcumin group received 1 g/day of simple curcumin, the phospholipidated curcumin group received 1 g/day of phospholipidated curcumin (containing 200 mg of pure curcumin), and the control group received 1 g/day of placebo. Serum PAB was measured before and after the intervention (at baseline and at 6 weeks). Data analyses were performed using spss software (version 16.0). Serum PAB increased significantly in the curcumin group (p < 0.001), but in the phospholipidated curcumin group, elevation of PAB level was not significant (p = 0.053). The results of our study did not suggest any improvement of PAB following supplementation with curcumin in MetS subjects. Copyright © 2017 John Wiley & Sons, Ltd.