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Bis(pyrene)-Doped Cationic Dipeptide Nanoparticles for Two-Photon-Activated Photodynamic Therapy

Sun, Bingbing, Wang, Lei, Li, Qi, He, Pingping, Liu, Huiling, Wang, Hao, Yang, Yang, Li, Junbai
Biomacromolecules 2017 v.18 no.11 pp. 3506-3513
biocompatible materials, cytotoxicity, energy transfer, fluorescence, fluorescent dyes, irradiation, nanoparticles, photochemotherapy, photons, photosensitizing agents, singlet oxygen
At present, one of main problems for photodynamic therapy (PDT) is how to improve the treatment depth. Two-photon activated (TPA) developed recently provide a possible solution for it. In this work, we report the energy-transferring assembled cationic dipeptide nanoparticles for two-photon activated photodynamic therapy (TPA-PDT). In the nanoparticles, the coencapsulated two-photon fluorescent dye bis(pyrene) (BP) is an energy donor, and a photosensitizer rose bengal (RB) is an acceptor based on an intraparticle fluorescence resonance energy transfer (FRET) mechanism. BP in the nanoparticles can be excited by one- or two- photon laser. And then, the energy of BP was transferred to RB, which highly enhanced the generation of singlet oxygen. The cellular experiments indicated that this nanosystem can induce the cytotoxicity under one- and two-photon irradiation, which allows further applications of FRET-based biomaterials for TPA-PDT.