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Molecular characterization of different equine-like G3 rotavirus strains from Germany

Author:
Pietsch, Corinna, Liebert, Uwe G.
Source:
Infection, genetics, and evolution 2018 v.57 pp. 46-50
ISSN:
1567-1348
Subject:
Rotavirus, animal and human health, children, feces, genes, genetic heterogeneity, genotype, human population, humans, phylogeny, viruses, Germany
Abstract:
The genetic heterogeneity of rotaviruses constitutes a substantial burden to human and animal health. Occasional interspecies transmissions can generate novel virus strains in the human population. We detected equine-like G3P[8] strains in feces sampled from three children in Germany in 2015 and 2016, respectively. Thereof two showed a DS-1-like backbone. In one strain the NSP2 gene segment was of distinct genotype (G3-P[8]-I2-R2-C2-M2-A2-N1-T2-E2-H2). Phylogenetic analyses of the German strains showed a relation to other equine-like G3 rotaviruses circulating in different countries. The reconstruction of reassortment events in the evolution of novel equine-like G3 rotaviruses suggests an independent introduction of the three strains into the local human rotavirus population.
Agid:
5859590