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α-Silyl Amides: Effective Bifunctional Lynchpins for Type I Anion Relay Chemistry

Author:
Montgomery, Thomas D., Smith, Amos B.
Source:
Organic letters 2017 v.19 no.22 pp. 6216-6219
ISSN:
1523-7052
Subject:
ambient temperature, amides, chemical reactions, chemical structure
Abstract:
Lynchpins comprising α-silyl amides have been validated for type I anion relay chemistry (ARC) to permit ready access to γ-ketoamides. Importantly, the ARC protocol can be run at ambient temperature without the need of additional reagents to trigger the [1,4] Brook rearrangement.
Agid:
5861125