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Enantioselective Rhodium(III)-Catalyzed Markovnikov Hydroboration of Unactivated Terminal Alkenes

Author:
Smith, James R., Collins, Beatrice S. L., Hesse, Matthew J., Graham, Mark A., Myers, Eddie L., Aggarwal, Varinder K.
Source:
Journal of the American Chemical Society 2017 v.139 no.27 pp. 9148-9151
ISSN:
1520-5126
Subject:
alkenes, boron compounds, enantioselectivity, esters, rhodium
Abstract:
We report the first enantioselective Rh-catalyzed Markovnikov hydroboration of unactivated terminal alkenes. Using a novel sp²–sp³ hybridized diboron reagent and water as a proton source, a broad range of alkenes undergo hydroboration to provide secondary boronic esters with high regio- and enantiocontrol.
Agid:
5864166