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Diastereoselective Synthesis of Functionalized Diketopiperazines through Post-transformational Reactions

Author:
Balalaie, Saeed, Ramezani Kejani, Reihaneh, Ghabraie, Elmira, Darvish, Fatemeh, Rominger, Frank, Hamdan, Fatima, Bijanzadeh, Hamid Reza
Source:
Journal of organic chemistry 2017 v.82 no.23 pp. 12141-12152
ISSN:
1520-6904
Subject:
chemical reactions, chemical structure, diastereoselective synthesis, diastereoselectivity, diketopiperazines, organic chemistry
Abstract:
A diversity-oriented access to diastereoselective arylidene 2,5-diketopiperazines is elaborated via a sequential Ugi post-transformation involving catalytic cyclization and oxidative Heck reaction sequence. This sequence offers an interesting multicomponent entry to a library of 2,5-diketopiperazines and arylidene 2,5-diketopiperazines under mild reaction conditions in good to excellent yields.
Agid:
5864506