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Bimetallic Cobalt–Rhodium Nanoparticle-Catalyzed Reductive Amination of Aldehydes with Nitroarenes Under Atmospheric Hydrogen
- Choi, Isaac, Chun, Supill, Chung, Young Keun
- Journal of organic chemistry 2017 v.82 no.23 pp. 12771-12777
- additives, aldehydes, amination, catalysts, chemical structure, cobalt, hydrogen, nanoparticles, nitroaromatic compounds, organic chemistry, rhodium
- A cobalt–rhodium heterobimetallic nanoparticle (Co₂Rh₂/C)-catalyzed tandem reductive amination of aldehydes with nitroaromatics to sec-amines has been developed. The tandem reaction proceeds without any additives under mild conditions (1 atm H₂ and 25 °C). This procedure can be scaled up to the gram scale, and the catalyst can be reused more than six times without loss of activity.