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Melanogenesis inhibitors from Coix lacryma-jobi seeds in B16-F10 melanoma cells

Amen, Yhiya, Arung, Enos Tangke, Afifi, Mohamed S., Halim, Ahmed F., Ashour, Ahmed, Fujimoto, Ryoji, Goto, Takahiro, Shimizu, Kuniyoshi
Natural product research 2017 v.31 no.23 pp. 2712-2718
Coix lacryma-jobi, adenine, bleaching agents, ethanol, melanin, melanogenesis, melanoma, phytopharmaceuticals, seeds, spectroscopy
An adenine derivative, 9-β-D-glucopyranosyl adenine, reported for the first time from a natural source, in addition to nine known compounds were isolated from the seeds of Coix lacryma - jobi . Their structures were elucidated based on extensive spectroscopic and chemical studies. The isolated compounds and the ethanol extract have been assayed for melanin inhibition using B16-F10 melanoma cell line. The results of our study suggested the potential use of Coix lacryma - jobi seeds as a skin whitening agent and reveal the seeds to be a rich source of important phytochemicals with melanogenesis inhibitory activity. Among the isolated compounds, coixol (2) and 2- O -β-glucopyranosyl-7-methoxy-2 H -1,4-benzoxazin-3(4 H)-one (8) exhibited potent melanogenesis inhibitory activity with no obvious melanocytotoxicity. The rest of the compounds showed weak to moderate activity.