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Chemical profiling and biological properties of Neolitsea kedahense Gamble essential oils

Author:
Jani, Nor Akmalazura, Sirat, Hasnah Mohd, Ahmad, Farediah, Mohamad Ali, Nor Azah, Jamil, Mailina
Source:
Natural product research 2017 v.31 no.23 pp. 2793-2796
ISSN:
1478-6427
Subject:
Bacillus subtilis, Neolitsea, alpha-glucosidase, antibacterial properties, enzyme inhibition, essential oils, gas chromatography-mass spectrometry, hydrodistillation, leaf oils, leaves, Malaysia
Abstract:
Hydrodistillation of the fresh stem and leaf of Neolitsea kedahense Gamble, collected from Gunung Jerai, Malaysia followed by the GC-FID and GC-MS analysis revealed the detection of a total of 47 constituents of which 28 (86.4%) from the stem and 31 (96.4%) constituents from the leaf. δ -Cadinene (17.4%), 1- epi -cubenol (11.8%), cyperotundone (9.0%), cis -cadin-4-en-7-ol (7.7%), τ -cadinol (7.1%) and α-cadinol (7.1%) were the principle constituents in the stem oil, whereas β -caryophyllene (18.9%), bicyclogermacrene (18.6%) and trans -muurola-4(14),5-diene (9.8%) were the major constituents in the leaf oil. Among the identified constituents, three constituents namely 7- epi -α-selinene, junenol and cis -cadin-4-en-7-ol have not been found previously from Neolitsea oils. The stem and leaf oils were screened for their α-glucosidase inhibitory and antibacterial activities. Both oils displayed potential α-glucosidase inhibitory activity, while the stem oil possessed weak antibacterial activity against Bacillus subtilis .
Agid:
5865389