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Phytotoxic, antibacterial, and antioxidant activities of mycotoxins and other metabolites from Trichoderma sp.
- Zhang, Ju-cheng, Chen, Guang-Yi, Li, Xiao-Zhan, Hu, Ming, Wang, Bang-Yan, Ruan, Bao-Hui, Zhou, Hao, Zhao, Li-Xing, Zhou, Jun, Ding, Zhong-Tao, Yang, Ya-Bin
- Natural product research 2017 v.31 no.23 pp. 2745-2752
- 2,2-diphenyl-1-picrylhydrazyl, Bacillus subtilis, Staphylococcus aureus, Trichoderma, antibacterial properties, antioxidant activity, cabbage, culture media, cytotoxicity, germination, inhibitory concentration 50, mass spectrometry, metabolites, mycotoxins, nuclear magnetic resonance spectroscopy, phytotoxicity, seeds, structure-activity relationships
- A new natural mycotoxin was isolated from the fermentation broth of Trichoderma sp. Jing-8 and the structure was determined as alternariol 1′-hydroxy-9-methyl ether (1), together with twelve known compounds. The structures were elucidated on the basis of their 1D, 2D NMR spectra and mass spectrometric data. Compounds 1 , 8 and 9 indicated inhibitions against germination of the seeds of cabbage with MICs < 3 μg/mL. The compound 1 showed the antibacterial activity against Bacillus subtilis and Staphylococcus aureus with MICs at 64 μg/mL. Compound 1 and 3 showed significant DPPH radical-scavenging activities with IC ₅₀ at 12 μg/mL, respectively. The OH at C-1′ in compound 1 decreased the cytotoxicity of these mycotoxins. A primary structure–activity relationship about the alternariol derivatives was discussed. Compounds 2 – 7 and 8 were the first time to be isolated from the Trichoderma .